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Neurosciences Seminar - Xiongwei Zhu, PhD
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Thu, Jan 29, 2026
12 PM – 1 PM EST (GMT-5)
Private Location (sign in to display)
Details
Thursday, January 29, 2026
12 PM, BRB 105
Xiongwei Zhu, PhD
Professor, Pathology
Case Western Reserve University School of Medicine
Host: Dr. Richard Zigmond
Lecture Title: "Abnormal Mitochondrial Dynamics As a Therapeutic Target for Alzheimer’s Disease"
Abstract: Multiple lines of evidence indicate that mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer disease. Recent studies demonstrated that mitochondria are highly dynamic organelles characterized by a delicate balance of fission and fusion, a concept that has revolutionized our basic understanding of the regulation of mitochondrial structure and function which has far-reaching significance in studies of health and disease. We found significant changes in the expression of mitochondrial fission and fusion proteins in AD brain. Both in vitro and in vivo studies suggest that mitochondrial dynamics was tipped towards fission and resulted in mitochondrial fission as well as abnormal mitochondrial distribution in AD models which likely contributes to mitochondrial and synaptic dysfunction as well as neuroinflammation in AD. We propose that abnormal mitochondrial dynamics plays a key role in causing the dysfunction of mitochondria that ultimately damage AD neurons. Therefore, abnormal mitochondrial dynamics may be an attractive therapeutic intervention target for AD.
Seminar Format
• Introduction by the host
• Presentation (approx. 45-50 min.)
Questions during the presentation are at the individual speaker’s discretion.
• 10-15 minutes of Q&A
We encourage students to ask the first questions.
Attendee Information
Free and open to the public. Seminars are not recorded.
Livestream will be available via Zoom for those who cannot attend in person.
Event updates and Zoom links are distributed through the Neurosciences seminar email list. Subscribe to our weekly announcements. https://case.edu/medicine/neurosciences/news-events/seminars-events
Questions - Neurosciences@case.edu
case.edu/medicine/neurosciences